26 Oct 2017 09:30am to 10:30am

Crosses, wedges, parallel lines and dog-legs: Designs, methods and issues arising in cluster randomised trials

Seminar
Event Location
Vernon Collins Lecture Theatre, Royal Children's Hospital
50 Flemington Road
Parkville VIC 3052
Australia
Speakers
Andrew is the current Head of the Biostatistics Unit in the Department of Epidemiology and Preventive Medicine at Monash University. Since completing a PhD in Statistics at Cornell University (USA)...

Cluster randomised trials have been implemented increasingly over the past 30 years or so.  More recently, design variants such as stepped wedge and crossover designs have been gaining favour (and flavour) due to emerging results that they have efficiency advantages over conventional parallel arm cluster randomised trials.  This talk will describe a number of variants of cluster randomised designs, placing analysis of data from these designs under a relatively simple statistical model commonly used in the literature.  This model is amenable to analytical decomposition of treatment effect estimators, leading to optimality considerations, and highlights the need for careful extensions to account for treatment effect heterogeneity.